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Updated: Jul 20, 2025

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Mouse Models for Human Herpesviruses.

Ivana Kutle^1,2, Anne Dittrich^1,3, Dagmar Wirth^1,2

¹Research Group Model Systems for Infection, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

Pathogens (Basel, Switzerland)

|July 29, 2023

Summary

Mouse models are crucial for studying human herpesvirus infections. Xenograft mouse models, using immunocompromised mice engrafted with human cells, offer a promising avenue for investigating these persistent viral infections and developing new treatments.

Keywords:

human herpesvirus humanized models interspecies models mouse models mouse orthologue viruses review xenografted mice

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Area of Science:

Virology
Immunology
Animal Models

Background:

Herpesviruses establish lifelong infections, posing significant health challenges.
Studying human herpesviruses in vivo requires appropriate animal models.
Existing mouse models have limitations for studying human-specific herpesviruses.

Purpose of the Study:

To review and evaluate various mouse models for studying human herpesvirus infections.
To highlight the potential and limitations of different models, particularly xenografts.
To discuss the application of immunocompromised xenograft mice in herpesvirus research.

Main Methods:

Review of existing literature on mouse models for herpesvirus research.
Description of natural mouse herpesviruses (MCMV, MHV-68, MRV).
Explanation of immunocompromised mouse models and xenotransplantation techniques.

Main Results:

Natural mouse herpesviruses are useful for studying herpesvirus biology in a natural host.
Human herpesviruses generally do not infect immunocompetent mice.
Immunocompromised xenograft mouse models enable the study of human-restricted herpesviruses.

Conclusions:

Mouse models are essential for understanding herpesvirus pathogenesis and treatment.
Xenograft mouse models significantly advance research on human herpesviruses.
Further refinement of these models will improve therapeutic strategies against herpesvirus infections.