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Updated: Jul 20, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Triple Negative Breast Cancer Treatment Options and Limitations: Future Outlook

Onyinyechi Obidiro1, Gantumur Battogtokh1, Emmanuel O Akala1

  • 1Center for Drug Research and Development, Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington, DC 20059, USA.

Pharmaceutics
|July 29, 2023
PubMed

Insights

Triple negative breast cancer (TNBC) is aggressive and challenging to treat due to drug resistance. Nanotechnology offers a promising avenue for developing more effective TNBC therapies.

Area of Science:

  • Oncology
  • Nanomedicine
  • Biochemistry

Background:

  • Triple negative breast cancer (TNBC) lacks expression of estrogen receptors (ER), progesterone receptors (PR), and HER2, leading to poorer survival rates.
  • Current TNBC treatments face limitations including drug resistance and off-target toxicity, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review current and potential treatment options for triple negative breast cancer (TNBC).
  • To explore the role of nanotechnology in overcoming challenges in TNBC treatment.

Main Methods:

  • Comprehensive literature review of TNBC characteristics and treatment modalities.
  • Analysis of chemotherapy, immunotherapy, targeted therapy, and nanoparticle-based approaches for TNBC.
  • Summary of future directions and potential solutions for TNBC management.

Main Results:

  • Chemotherapy, particularly with anthracyclines and taxanes, is a primary TNBC treatment but faces resistance and toxicity issues.
  • Nanotechnology presents a potential solution to enhance drug delivery and efficacy while minimizing side effects in TNBC treatment.
  • Combination therapies and emerging strategies show promise for improving TNBC patient outcomes.

Conclusions:

  • Effective treatment of TNBC requires a multidisciplinary approach addressing its molecular diversity and aggressive nature.
  • Nanoparticle-based therapies hold significant potential for advancing TNBC treatment by improving drug targeting and reducing toxicity.
  • Continued research and collaboration are crucial for developing next-generation therapies for triple negative breast cancer.
Keywords:
chemotherapyimmunotherapylimitationsnanotechnologytriple negative breast cancer

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