Controlled Delivery of Celecoxib-β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Area of Science:

• Materials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Nanostructured titanium dioxide (TiO2) shows promise for drug delivery applications.
• Celecoxib, an anti-inflammatory drug, can be formulated into inclusion complexes with beta-cyclodextrin.
• Developing effective drug delivery systems is crucial for targeted and sustained drug release.

Purpose of the Study:

• To create a functional drug delivery system using anodic TiO2 for celecoxib and its beta-cyclodextrin complex.
• To optimize the composition of celecoxib-beta-cyclodextrin complexes.
• To evaluate the drug release profile from TiO2 nanostructures.

Main Methods:

• Synthesis and characterization of celecoxib-beta-cyclodextrin complexes using ITC, DSC, FT-IR, 1H NMR, and SEM.
• Electrochemical oxidation to synthesize nanostructured TiO2 layers (60 nm pore diameter, 1.60 µm thickness).
• Loading TiO2 layers with pure celecoxib and the celecoxib-beta-cyclodextrin complex, followed by release studies.

Main Results:

• Optimal composition of celecoxib-beta-cyclodextrin complexes was determined.
• Nanostructured TiO2 layers were successfully synthesized and characterized.
• Effective drug release of celecoxib from TiO2 layers was observed over 24 hours, with an initial burst release followed by continuous release.

Conclusions:

• Nanostructured TiO2 serves as an effective drug delivery system for celecoxib, particularly when complexed with beta-cyclodextrin.
• This system offers a viable approach for sustained drug availability, potentially aiding in pain management, such as in orthopedic surgery.
• The combination of TiO2 nanostructures and beta-cyclodextrin-celecoxib complexes presents a promising advanced drug delivery platform.