Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

891
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
891
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

505
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
505
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

154
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
154
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution01:09

One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

335
The one-compartment open model is a simplified approach used in pharmacokinetics to understand the distribution and elimination of a drug administered through an intravenous bolus. This model assumes rapid drug dispersal throughout the body and elimination using a first-order process. Key pharmacokinetic parameters, such as the elimination rate constant (k), half-life (t1/2), and the apparent volume of distribution (Vd), can be estimated from this model. The elimination rate is calculated...
335
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

3.8K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Solvatochromic-Chemometric Framework to Resolve Subtle Polarity Microenvironment Differences in Cycloalkanes Driven by Molecular Conformation and Substituent Effects: A Proof-Of-Concept for Advanced Aviation Fuel Design.

The journal of physical chemistry. B·2026
Same author

Investigating the effect of solvent polarity environment differences in electrolyte and non-electrolyte systems.

Journal of pharmaceutical sciences·2025
Same author

Enhancing drug solubilization using a surface-modified edible biopolymer through hot melt extrusion: A design space methodology.

Journal of pharmaceutical sciences·2025
Same author

Development of an excipient polarity screening tool for protein formulations via solvatochromism.

Journal of pharmaceutical sciences·2025
Same author

Octenyl succinic anhydride-modified starches as emulsifier agents: A comparative study emphasizing stability, rheology, and emulsion´s microstructure.

Journal of pharmaceutical sciences·2025
Same author

Fast-dissolving electrospun cellulose fiber-based matrices as modular oral dosage forms.

Journal of pharmaceutical sciences·2025

Related Experiment Video

Updated: Jul 20, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.4K

Tunable Drug Release Rate Using Modular Oral Dosage Forms.

Mario A Cano-Vega1, Laura M Arango-Salazar2, Rodolfo Pinal2

  • 1Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.

Pharmaceutics
|July 29, 2023
PubMed
Summary

New oral dosage forms allow adjustable drug release profiles for poorly-soluble drugs like progesterone (PGR). This modular approach fine-tunes drug delivery, optimizing bioavailability and creating patient-centric formulations.

Keywords:
additive manufacturingcontrolled releasedrug release kineticsmodular dosage formsmulti-layerpharmaceutical filmssolubilityspring-parachute

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

919

Related Experiment Videos

Last Updated: Jul 20, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.4K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

919

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Poorly-soluble drugs present challenges in achieving optimal bioavailability.
  • Conventional oral dosage forms often have fixed drug release profiles.
  • Developing adjustable release mechanisms is crucial for personalized medicine.

Purpose of the Study:

  • To develop a novel modular oral dosage form with adjustable drug release profiles.
  • To utilize progesterone (PGR) as a model poorly-soluble drug.
  • To fine-tune drug release rates for enhanced bioavailability and patient-centric formulations.

Main Methods:

  • Preparation of oral dosage forms as stack assemblies of functional modules.
  • Modules fabricated as progesterone-carrying hydroxypropyl methylcellulose (HPMC) films.
  • Two types of HPMC films (fast and slow release) utilized based on HPMC grade.
  • Drug loading controlled by the number of modules; release profile adjusted by module proportion.

Main Results:

  • Successfully created multi-layer assemblies with tunable drug release rates.
  • Demonstrated a wide range of release profiles bracketed by fast and slow release extremes.
  • Proportion of fast vs. slow release modules effectively controlled the overall release rate.

Conclusions:

  • The modular assembly approach offers a versatile method for adjusting drug release profiles.
  • This technology is suitable for optimizing bioavailability of poorly-soluble drugs.
  • The developed system facilitates the creation of patient-centric oral formulations.