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Fast-dissolving electrospun cellulose fiber-based matrices as modular oral dosage forms.

Mario A Cano-Vega1, Héctor Lozano-Perez2, Rodolfo Pinal3

  • 1Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.

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|July 20, 2025
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Summary

This study presents a new modular oral dosage platform using fast-dissolving electrospun hydroxypropyl methylcellulose (HPMC)/polyethylene oxide (PEO) fibers for controlled drug delivery of poorly soluble drugs.

Keywords:
Amorphous solid dispersionCelluloseDrug deliveryElectrospinningPolymeric fibers

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • Fast-dissolving oral dosage forms offer advantages for delivering poorly water-soluble drugs.
  • Developing advanced platforms is crucial for controlled and customizable drug release.

Purpose of the Study:

  • To introduce a novel modular oral dosage platform using electrospun hydroxypropyl methylcellulose (HPMC)/polyethylene oxide (PEO) fibers.
  • To characterize and optimize the fabrication of drug-loaded HPMC/PEO fibers.
  • To demonstrate the integration of these fibers into a bilayer module for enhanced drug delivery.

Main Methods:

  • Fabrication and optimization of electrospun HPMC/PEO fibers using dichloromethane/ethanol and water/ethanol solvent systems.
  • Loading of model compounds with varying solubility profiles into the fibers.
  • Characterization using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD).
  • Dissolution studies to evaluate drug release kinetics.
  • Development of an integrated bilayer module by depositing drug-loaded fibers onto a non-drug-loaded HPMC film.

Main Results:

  • Successful fabrication of drug-loaded HPMC/PEO fibers exhibiting amorphization of the model compounds.
  • Characterization confirmed bead-free fiber morphology and reduced crystallinity.
  • Dissolution studies showed rapid disintegration and efficient drug release from the electrospun fibers.
  • The integrated bilayer module maintained desirable fibrous layer properties and fast dissolution.

Conclusions:

  • Drug-loaded electrospun HPMC/PEO fibers demonstrate significant potential as an advanced drug delivery system.
  • This platform enables controlled and customizable drug delivery through modular oral dosage forms.
  • The findings support the development of next-generation oral drug delivery technologies.