Biocompatible Palladium Nanoparticles Prepared Using Vancomycin for Colorimetric Detection of Hydroquinone

Area of Science:

• Nanotechnology
• Analytical Chemistry
• Biomedical Engineering

Background:

• Hydroquinone is a human health threat and resistant to degradation.
• Convenient and sensitive detection methods for hydroquinone are crucial.

Purpose of the Study:

• To develop a novel colorimetric method for hydroquinone detection.
• To utilize peroxidase-like palladium nanozymes (Pd nanozymes) for this purpose.

Main Methods:

• Synthesized vancomycin-stabilized palladium nanoparticles (Van-Pd(n) NPs).
• Characterized NPs using UV-vis spectrophotometry, TEM, and XRD.
• Assessed NP biocompatibility via MTT assay.
• Evaluated the peroxidase-like activity of Van-Pd2 NPs for hydroquinone detection.

Main Results:

• Successfully synthesized Van-Pd(n) NPs with controlled sizes.
• Van-Pd2 NPs demonstrated excellent biocompatibility.
• Van-Pd2 NPs exhibited significant peroxidase-like activity.
• Achieved a low detection limit of 0.323 μM for hydroquinone.

Conclusions:

• Vancomycin enhances the peroxidase-like activity and biocompatibility of Pd nanozymes.
• Van-Pd2 NPs offer a promising tool for the colorimetric detection of hydroquinone.
• The developed method is reliable and sensitive for hydroquinone analysis.