Related Experiment Video
Updated: Jul 20, 2025

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Pulmonary Artery Aneurysm Associated With Aspergilloma in a Patient Diagnosed With Granulomatosis With Polyangiitis
Ashbina Pokharel1, Indira Acharya2, Joseph Skender3
1Internal Medicine, Beaumont Hospital, Royal Oak, USA.
Abstract:
Granulomatosis with polyangiitis (GPA) is an autoimmune, necrotizing granulomatous disease that affects small- and medium-sized blood vessels. Aspergilloma is a fungal mass of Aspergillus and usually found in the preexisting cavity in lung parenchyma. Surgical resection is the mainstay of treatment of aspergilloma. In this article, we present a case of a 70-year-old male with GPA and aspergilloma who presented with massive, life-threatening hemoptysis. Further workup with a chest computed tomography (CT) pulmonary angiogram demonstrated a pulmonary artery pseudoaneurysm along the wall of the lung cavity which was emergently managed with embolization and required monitoring in the medical intensive care unit. This case report alerts clinicians to maintain a high level of suspicion for an aneurysm if the degree of hemoptysis is higher than expected.
Insights
Granulomatosis with polyangiitis (GPA) and aspergilloma can cause severe lung bleeding. A pulmonary artery pseudoaneurysm was identified as the cause in a patient with GPA and aspergilloma, requiring urgent embolization.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Autoimmune Diseases
Background:
- Granulomatosis with polyangiitis (GPA) is a rare autoimmune disorder affecting small- to medium-sized blood vessels.
- Aspergilloma, a fungal ball caused by Aspergillus, typically colonizes pre-existing lung cavities.
- Both conditions can lead to significant respiratory complications, including hemoptysis.
More Related Videos
Related Concept Videos
Aneurysm I: Introduction
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Aneurysm III: Interprofessional Care
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...

