Related Experiment Video
Updated: Jul 20, 2025
11:07
Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
2.9K
Extrusion-based systems for topical and transdermal drug delivery
Ana Luiza Lima1, Idejan P Gross1, Lívia Lira de Sá-Barreto1
1Laboratory of Food, Drugs, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.
Expert Opinion on Drug Delivery
|July 31, 2023
Summary
Extrusion-based techniques like hot-melt extrusion (HME) and fused deposition modeling (FDM) 3D printing offer innovative solutions for topical and transdermal drug delivery by enhancing drug diffusion through skin barriers. These methods enable patient-matched devices and improved bioavailability, despite some limitations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biotechnology
Background:
- Transdermal drug delivery presents a safe, non-invasive route for systemic or local therapeutic effects.
- Developing effective topical formulations that overcome skin's natural barrier remains a significant challenge in pharmaceutical science.
Purpose of the Study:
- To provide a comprehensive overview of extrusion-based techniques for developing advanced topical and transdermal drug delivery systems.
- To examine the theoretical principles behind enhanced drug permeation facilitated by extrusion methods.
- To contrast current extrusion-based pharmaceutical processes with established manufacturing techniques.
Main Methods:
- Review of extrusion-based techniques, focusing on hot-melt extrusion (HME) and fused deposition modeling (FDM) 3D printing.
- Analysis of theoretical models for drug diffusion and skin permeation enhancement.
- Comparative assessment of HME and FDM 3D printing against conventional pharmaceutical manufacturing.
Main Results:
- Extrusion techniques enable unique drug-excipient interactions, optimizing drug diffusion across skin barriers.
- Hot-melt extrusion (HME) and FDM 3D printing allow for the creation of novel dosage forms, including those with precise anatomical fit.
- These methods offer advantages in industrial scalability and bioavailability enhancement for transdermal therapies.
Conclusions:
- Extrusion-based technologies, particularly HME and FDM 3D printing, represent a significant advancement in topical and transdermal drug delivery.
- While challenges like thermal stability and excipient selection exist, the benefits of industrial adaptability and patient-matched devices warrant further investment.
- These innovative techniques hold promise for improving therapeutic outcomes and patient compliance in drug delivery.
Keywords:
3D printingcutaneous permeationfused deposition modelinghot-melt extrusionskin drug-deliveryMore Related Videos
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
383
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
383
01:16Drug Delivery: Overview
323
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
323
01:15Non-Oral Extravascular Drug Absorption Routes
239
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
239
01:29Drug Delivery: Parenteral Route
619
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
619
01:22Routes of Drug Administration: Overview
6.4K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
6.4K
01:18Drug Delivery: Enteral Route
505
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
505