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Fluorene-based tau fibrillation sensor and inhibitor with fluorogenic and photo-crosslinking properties
Qiuxuan Xia1,2, Zhiming Wang1,3, Wang Wan1
1CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China. liuyu@dicp.ac.cn.
Chemical Communications (Cambridge, England)
|July 31, 2023
Abstract:
Tau protein aggregation into neurofibrillary tangles often causes tauopathies. Herein, we report fluorene based sensors with fluorogenicity upon binding to tau proteins. Intriguingly, these sensors possess triplet state properties to inhibit tau fibrillation upon photo-induced crosslinking.
