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Revaccination for Hepatitis B in Previous Nonresponders Following Hepatitis C Eradication
Jesse G Powell1, Spencer R Goble2, Jose D Debes1,3
1Department of Gastroenterology and Hepatology, Hennepin Healthcare, Minneapolis, Minnesota, USA.
Background:
Patients with chronic hepatitis C virus (HCV) do not respond to hepatitis B virus (HBV) vaccination as efficiently as the general population. We assessed if revaccination after HCV treatment resulted in improved response.
Methods:
Previous HBV vaccine nonresponders were prospectively recruited for revaccination after HCV eradication. Hepatitis B surface antibody (HBsAb) testing was performed 1 month after series completion.
Results:
Follow-up HBsAb testing was performed in 31 of 34 enrolled patients with 21 (67.7%) reactive results. There were no significant differences in HBsAb reactivity based on age, sex, race, or advanced fibrosis presence.
Conclusions:
HBV vaccine nonresponders should be considered for revaccination following HCV cure.
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