Related Experiment Video

Updated: Jul 20, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K

Angiotensinogen, Angiotensin-Converting Enzyme, and Chymase Gene Polymorphisms as Biomarkers for Basal Cell Carcinoma

Christos Yapijakis1,2,3,4, Iphigenia Gintoni5,6,7, Sevastiana Charalampidou5,6

  • 1Unit of Orofacial Genetics, 1st Department of Pediatrics, National Kapodistrian University of Athens, "Hagia Sophia" Children's Hospital, Athens, Greece. cyapi@med.uoa.gr.

Advances in Experimental Medicine and Biology
|July 31, 2023
PubMed
Abstract

Insights

Certain genetic variations in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and chymase (CMA1) genes are linked to an increased risk of basal cell carcinoma (BCC). These polymorphisms correlate with higher angiotensin II (AngII) levels, suggesting a role in BCC development.

Area of Science:

  • Genetics
  • Dermatology
  • Cardiovascular Research

Background:

  • Antihypertensive drugs like ACE inhibitors and angiotensin II receptor blockers reduce basal cell carcinoma (BCC) risk.
  • This suggests a potential role for angiotensin II (AngII) in BCC tumorigenesis.

Purpose of the Study:

  • To investigate the genetic association between BCC development and functional DNA polymorphisms in genes regulating AngII production.
  • Specifically examining AGT (M235T), ACE (I/D), and CMA1 (A1903G) polymorphisms.

Main Methods:

  • A case-control study was conducted with 203 unrelated Greek individuals.
  • The study included 100 patients diagnosed with BCC and 103 healthy controls matched for demographic factors.

Main Results:

  • The AGT-M235T polymorphism showed a significantly higher prevalence of the MT genotype in BCC patients (78.0%) compared to controls (28.3%).
  • The ACE-I/D polymorphism revealed an increased frequency of the DD genotype in BCC patients (72.8%) versus controls (46.2%).
  • The CMA1-A1903G polymorphism demonstrated a significantly higher frequency of the AG genotype in BCC patients (86%) compared to controls (50.5%).

Conclusions:

  • The MT, DD, and AG genotypes of AGT, ACE, and CMA1 polymorphisms, respectively, were significantly more frequent in BCC patients.
  • These genotypes are associated with increased enzyme activity and elevated AngII levels.
  • These findings suggest that these specific genotypes may serve as reliable biomarkers for increased BCC risk.
Keywords:
A1903GACEAGTAngiotensin IIBasal cell carcinomaCMA1CancerGenetic associationI/DM235T

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.6K
Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.3K

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
692
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.6K