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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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[Individualized precision medicine].

Bernd Wullich1,2, Helge Taubert3,4, Peter J Goebell3,4

  • 1Klinik für Urologie und Kinderurologie, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, 91054, Erlangen, Deutschland. bernd.wullich@uk-erlangen.de.

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Summary
This summary is machine-generated.

Personalized medicine, driven by molecular testing and next-generation sequencing, is revolutionizing disease diagnosis and treatment. This technology identifies biomarkers and guides targeted therapies for improved patient outcomes.

Keywords:
BiomarkersCancerLiquid biopsyNext generation sequencingPSMA

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Area of Science:

  • Genomics and Molecular Biology
  • Oncology
  • Pharmacogenomics

Context:

  • Personalized medicine has significantly advanced disease diagnosis and treatment paradigms.
  • Molecular testing, particularly next-generation sequencing (NGS), is a cornerstone of personalized medicine.
  • NGS analyzes tissue and liquid samples for diagnostic, prognostic, and predictive biomarker determination.

Purpose:

  • To highlight the revolutionary impact of personalized medicine and molecular testing.
  • To explain the role of next-generation sequencing in identifying biomarkers.
  • To discuss the application of targeted therapies and resistance prediction.

Summary:

  • Next-generation sequencing (NGS) enables precise molecular profiling of patient samples.
  • Biomarker identification via NGS supports diagnostic, prognostic, and predictive applications.
  • NGS facilitates targeted therapies and informs treatment decisions, including avoiding ineffective treatments due to resistance.

Impact:

  • Advances in personalized medicine are transforming patient care and treatment strategies.
  • Molecular testing improves treatment efficacy through targeted therapies.
  • New molecular imaging techniques enhance understanding of tumor progression and targeted treatment development.