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Updated: Jul 20, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Disease Diagnosis Based on Nucleic Acid Modifications.

Xiaochen Xue¹, Zhiying Wang^1,2, Yafen Wang³

¹College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

ACS Chemical Biology

|August 1, 2023

Summary

This summary is machine-generated.

Nucleic acid modifications, including epigenetic and epitranscriptomic factors, influence biological processes and human disorders like cancer. Their potential as diagnostic biomarkers in clinical therapy is an evolving area of research.

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Area of Science:

Molecular Biology
Epigenetics
Biochemistry

Background:

Nucleic acid modifications are crucial epigenetic and epitranscriptomic factors impacting biological inheritance, growth, and metabolism.
Recent advancements in mapping and characterizing these modifications have facilitated large-scale studies, particularly in humans.
These modifications have demonstrated significant implications in human disorders, notably cancer.

Purpose of the Study:

To review classical nucleic acid modifications.
To highlight progress in utilizing nucleic acid modifications as diagnostic biomarkers in clinical therapy.
To provide perspectives on the future development of these biomarkers.

Main Methods:

Literature review of classical and recent nucleic acid modification studies.
Analysis of research on nucleic acid modifications in relation to human disorders.
Exploration of diagnostic and therapeutic applications.

Main Results:

Nucleic acid modifications play a significant role in fundamental biological processes.
Advanced techniques have enabled detailed characterization of these modifications.
Evidence suggests a strong link between nucleic acid modifications and diseases like cancer.

Conclusions:

Nucleic acid modifications are increasingly recognized for their impact on health and disease.
The potential for nucleic acid modifications to serve as novel diagnostic biomarkers is a key area of investigation.
Further research is warranted to fully realize their prospects in clinical therapy.