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Effectiveness and Safety of Ustekinumab for Pediatric Inflammatory Bowel Disease: A Systematic Review

Shengbo Fang1, Sixi Zhang1, Chunyan Zhang2

  • 1Department of Clinical Pharmacy, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin, China.

Paediatric Drugs
|August 1, 2023
PubMed

Insights

Ustekinumab shows potential for pediatric inflammatory bowel disease (IBD), with about half of patients achieving remission at one year. Further high-quality research is needed to confirm long-term benefits and optimize dosing for Crohn's disease and ulcerative colitis.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Ustekinumab use in pediatric inflammatory bowel disease (IBD) is off-label with limited existing data.
  • This systematic review evaluates the efficacy and safety of ustekinumab in pediatric IBD patients.

Conclusions:

  • Ustekinumab demonstrates a reasonable safety profile in pediatric IBD, with approximately half of patients achieving remission at one year.
  • Dose optimization is frequently necessary, and low-quality evidence highlights the need for more high-quality data.
  • Further research is required to establish long-term benefits and efficacy in pediatric CD and UC/IBD-U.
Abstract

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