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Updated: Jun 21, 2026
High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
Recent Progress on One-Pot Multisubstrate Screening
Matisyahu S Fogel1, Kazunori Koide1
1Department of Chemistry, University of Pittsburgh 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
Abstract:
Traditionally, new synthetic reactions have been developed using a model substrate to screen reaction conditions before testing the optimized conditions with a range of more complex substrates. In 1998, Gao and Kagan pooled multiple substrates in one pot to study the generality of an enantioselective method. Although such one-pot multisubstrate screenings may be powerful, few applications have appeared in the literature. With the advancement of various chromatography techniques, it may be time to revisit this underutilized platform. This review article discusses the applications of one-pot multisubstrate screenings as a method for developing new synthetic methods.
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