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Polylactic Acid-Based Biomaterials in Wound Healing: A Systematic Review
Hui Ling Chen1, Joanne Wai Yee Chung, Vincent Chun Man Yan
1Hui Ling Chen, BS is Master of Philosophy Student, School of Nursing and Health Studies, Hong Kong Metropolitan University. Joanne Wai Yee Chung, PhD, RN, is Professor, Hong Kong Nang Yan College of Higher Education. Vincent Chun Man Yan, MSc, is Senior Lecturer, School of Nursing and Health Studies, Hong Kong Metropolitan University. Thomas Kwok Shing Wong, PhD, RN, is Professor, Hong Kong Nang Yan College of Higher Education. The authors have disclosed no financial relationships related to this article. Submitted August 18, 2022; accepted in revised form November 4, 2022; published ahead of print July 24, 2023.
Objective:
To examine (1) the effectiveness of polylactic acid (PLA)-based biomaterials in wound healing, (2) their effects on wound infection prevention, and (3) their safety compared with existing biomaterials.
Data Sources:
Data sources included PubMed, MEDLINE, Cochrane Library, CINAHL (Cumulative Index to Nursing and Allied Health Literature), CNKI (China National Knowledge Infrastructure), WEIPU, and WANFANG databases.
Study Selection:
Investigators included 14 studies discussing the effects of PLA-based biomaterials in cutaneous wound healing published from 2000 to 2021.
Data Extraction:
Authors extracted the following information from the selected studies: general information, study type, type of wound, PLA-based biomaterials and techniques, study period, outcome measures, and results.
Data Synthesis:
Polylactic acid-based biomaterials may promote wound healing through wound area repair, collagen deposition, angiogenesis, and cell activities, which are related to the good biocompatibility, biodegradability, and moisture management properties of PLA. A proper product structure may also help. Both the native PLA materials and PLA blends seem to be antibacterial, although more evidence is needed for the native PLA products. Because there was no severe adverse event or obvious cytotoxicity observed in the included studies, PLA-based biomaterials are likely safe.
Conclusions:
Polylactic acid-based biomaterials may be good wound dressing materials, although more evidence is needed to support their broader application in wound care.
