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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
Reference Ranges of Ventricular Morphology and Function in Healthy Chinese Adults: A Multicenter 3 T MRI Study
Ziqian Xu1,2, Weihao Li1, Jiaqi Wang1
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Insights
This study established magnetic resonance imaging (MRI) reference ranges for heart structure and function in Chinese adults. Results reveal significant differences based on sex and age, crucial for accurate clinical interpretation.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Population Health
Background:
- Lack of established magnetic resonance imaging (MRI) reference ranges for ventricular morphology and function in the Chinese population.
- Need for population-specific data to ensure accurate interpretation of cardiac MRI findings.
Purpose of the Study:
- To establish comprehensive MRI reference ranges for left and right ventricular (LV and RV) morphology and function.
- Utilize a large, multicenter cohort of healthy Chinese adults for robust data collection.
Main Methods:
- Prospective study involving 1012 healthy Chinese Han adults.
- Acquisition of cardiac MRI using a balanced steady-state free procession cine sequence at 3.0 Tesla.
- Measurement of biventricular volumes, mass, dimensions, wall thickness, and ejection fractions, indexed to body surface area and height.
Main Results:
- Significant differences in biventricular volumes and mass were observed between males and females, even after body surface area (BSA) indexing.
- Males exhibited larger ventricular volumes and mass, while females had significantly lower values.
- Age demonstrated a significant negative correlation with biventricular volumes in both sexes, with notable sex-specific correlations for ejection fractions.
Conclusions:
- Established MRI reference ranges for biventricular morphology and function in Chinese adults.
- Demonstrated significant associations between cardiac parameters, age, and sex.
- These findings are essential for improving the diagnostic accuracy of cardiac MRI in the Chinese population.
Background:
Magnetic resonance imaging (MRI) reference ranges for ventricular morphology and function in the Chinese population are lacking.
Purpose:
To establish the MRI reference ranges of left and right ventricular (LV and RV) morphology and function based on a large multicenter cohort.
Study Type:
Prospective.
Population:
One thousand and twelve healthy Chinese Han adults.
Field Strength/Sequence:
Balanced steady-state free procession cine sequence at 3.0 T.
Assessment:
Biventricular end-diastolic, end-systolic, stroke volume, and ejection fraction (EDV, ESV, SV, and EF), LV mass (LVM), end-diastolic and end-systolic dimension (LVEDD and LVESD), anteroseptal wall thickness (AS), and posterolateral wall thickness (PL) were measured. Body surface area (BSA) and height were used to index biventricular parameters. Parameters were compared between age groups and sex.
Statistical Tests:
Independent-samples t-tests or Mann-Whitney U test to compare mean values between sexes; ANOVA or Kruskal-Wallis test to compare mean values among age groups; linear regression to assess the relationships between cardiac parameters and age (correlation coefficient, r). A P value <0.05 was considered statistically significant.
Results:
The biventricular volumes, LVM, LVEDD, RVEDV/LVEDV ratio, LVESD, AS, and PL were significantly greater in males than in females, even after indexing to BSA or height, while LVEF and RVEF were significantly lower in males than in females. For both sexes, age was significantly negatively correlated with biventricular volumes (male and female: LVEDV [r = -0.491; r = -0.373], LVESV [r = -0.194; r = -0.184], RVEDV [r = -0.639; r = -0.506], RVESV [r = -0.270; r = -0.223]), with similar correlations after BSA normalization. LVEF (r = 0.043) and RVEF (r = 0.033) showed a significant correlation with age in females, but not in males (P = 0.889; P = 0.282).
Data Conclusion:
MRI reference ranges for biventricular morphology and function in Chinese adults are presented and show significant associations with age and sex.
Level Of Evidence:
2 TECHNICAL EFFICACY: Stage 2.
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