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Updated: Jul 20, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Digital Manufacturing of Functional Ready-to-Use Microfluidic Systems.

Vahid Karamzadeh^1,2, Ahmad Sohrabi-Kashani^1,2, Molly Shen^1,2

¹Biomedical Engineering Department, McGill University, Montreal, QC, H3A 0G1, Canada.

Advanced Materials (Deerfield Beach, Fla.)

|August 2, 2023

Summary

This summary is machine-generated.

Additive digital manufacturing enables the low-cost, rapid production of fully functional, monolithic capillaric circuits (CCs). This breakthrough in 3D printing microfluidics eliminates the need for external pumps and transient surface treatments.

Keywords:

3D printing capillaric circuits diagnostics digital manufacturing functional microfluidics hydrophilic ink

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Last Updated: Jul 20, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Area of Science:

Microfluidics
Additive Manufacturing
Materials Science

Background:

Digital manufacturing (DM) has potential for microfluidics but faces challenges with resolution and peripheral dependence.
Capillaric circuits (CCs) are self-contained microfluidic systems relying on tailored hydrophilicity.
Current CC hydrophilization methods (plasma treatment) are transient, irreproducible, and limit design.

Purpose of the Study:

To report the additive DM of monolithic, intrinsically hydrophilic CCs using 3D printing.
To introduce novel designs for capillary valves and bubble-free conduits.
To demonstrate the integration of capillary pumps within the CC structure.

Main Methods:

3D printing of CCs using a poly(ethylene glycol)diacrylate ink with hydrophilic acrylic acid crosslinkers.
Development of a robust capillary valve and circular-section embedded conduits.
Integration of a porous gyroid structure for an embedded capillary pump.

Main Results:

Successfully fabricated monolithic, fully functional, and intrinsically hydrophilic CCs.
Demonstrated a new capillary valve design and bubble-free conduits.
Achieved elimination of external pumps by embedding capillary pump structures.
Illustrated CC functionality with an immunoassay.

Conclusions:

Additive DM offers a rapid (under 30 min), low-cost, and distributed method for producing ready-to-use microfluidic systems.
Monolithic CCs with embedded capillary pumps and robust valves are now feasible.
This approach significantly advances the accessibility and applicability of microfluidic devices.