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Synthetic strategies for the construction of C3-fluorinated oxindoles
Deeksha1, Bittu1, Ritesh Singh1
1Department of Chemistry, Central University of Rajasthan, Ajmer, Rajasthan 305817, India. ritesh.singh@curaj.ac.in.
Abstract:
C3-fluorinated oxindoles are important scaffolds known to demonstrate various biological properties. As bio-isosteres of oxindoles, these compounds have shown tremendous potential in drug research discovery programs. Besides, they also serve as starting materials for synthesizing other fluorine-containing new architectures, thus launching research for developing new methods for their synthesis. Consequently, various approaches have been developed over the years to synthesize C3-fluorinated oxindoles. This review highlights the strategies developed to date to access C3-difluoro and monofluorooxindoles via intermolecular and intramolecular approaches. The key findings of the strategies developed are discussed along with the prevailing mechanism.
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