Capillary self-aspirating electrospray ionization (CSESI) for convenient and versatile mass spectrometry analysis

Area of Science:

• Analytical Chemistry
• Mass Spectrometry
• Surface Science

Background:

• Electrospray ionization (ESI) is a crucial technique in mass spectrometry.
• Simplifying ESI can broaden its accessibility and application.
• Conventional ESI often requires complex sample introduction systems.

Purpose of the Study:

• To develop a simplified ESI source using capillary action for sample introduction.
• To enhance the efficiency and stability of the developed CSESI source.
• To demonstrate the applicability of CSESI in routine analysis and complex sample matrices.

Main Methods:

• Development of a capillary self-aspirating electrospray ionization (CSESI) source.
• Utilizing capillary action for spontaneous sample introduction, negating the need for pumps.
• Modification of glass capillaries using cold plasma processing and platinum sputtering for improved performance.
• Application of high voltage (HV) through a platinum-coated capillary tip.

Main Results:

• CSESI enables pump-free, self-aspirating sample introduction via capillary action.
• Cold plasma and platinum sputtering treatments enhance capillary hydrophilicity and HV application, ensuring stable electrospray.
• CSESI demonstrates low sample consumption and inherent physical filtration.
• Successful application in real-time monitoring of chemical reactions and direct analysis of muddy soil solutions.

Conclusions:

• CSESI offers a simplified, efficient, and stable alternative to conventional ESI sources.
• The technique is suitable for routine ESI-mass spectrometry (MS) analysis and direct analysis of challenging samples.
• CSESI's design facilitates broader adoption of ESI techniques in various scientific fields.