[Nosological characteristics of the morphogenesis of nephrosclerosis]

Morphology of nephrosclerosis at its early stage is characterized by nosologic specificity. Morphogenetic mechanisms of glomerulosclerosis vary greatly and depend on the specific feature of the disease pathogenesis, underlying nephrosclerosis. Stromal sclerosis of renal cortex stroma is associated with the increase in collagen-synthesizing function of interstitial fibroblasts. At the late stages of nephrosclerosis all renal tissue structures are equally affected with sclerosis, resulting in loss of nosologic specificity of the process. Arterial hypertension favours the progression of nephrosclerosis.