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Updated: Jul 20, 2025
09:44
Oral Biofilm Analysis of Palatal Expanders by Fluorescence In-Situ Hybridization and Confocal Laser Scanning Microscopy
Published on: October 20, 2011
16.1K
Illuminating the oral microbiome: cellular microbiology.
Richard J Lamont1, Daniel P Miller2, Juhi Bagaitkar3,4
1Department of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY, KY40202, United States.
FEMS Microbiology Reviews
|August 3, 2023
Summary
Epithelial cells interact with microbes, sensing the microbiome and alerting the immune system. This cellular microbiology field explores host-microbe communication and bacterial invasion strategies.
Area of Science:
- Microbiology
- Cell Biology
- Immunology
Background:
- Epithelial cells form a barrier in the gingival crevice against microorganisms.
- These cells actively sense and communicate microbiome composition to the innate immune system.
- Microorganisms manipulate host cell signaling for colonization and survival.
Purpose of the Study:
- To explore the interactive interface between epithelial cells and colonizing microorganisms.
- To understand how epithelial cells sense and communicate microbial information.
- To investigate bacterial strategies for manipulating host cell signaling.
Main Methods:
- Cellular microbiology techniques.
- Analysis of host-microbe interactions at the cellular level.
- Study of signal transduction pathways.
Main Results:
- Epithelial cells are interactive interfaces, not just passive barriers.
- Microorganisms employ strategies to manipulate host cell signaling.
- Cellular microbiology reveals insights into epithelial cell physiology and host responses.
Conclusions:
- Epithelial cells play a dynamic role in sensing and responding to the microbiome.
- Understanding these interactions is crucial for comprehending host defense and microbial pathogenesis.
- The field of cellular microbiology offers significant insights into host-microbe dynamics.
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