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Wernicke Encephalopathy: An Updated Narrative Review
Elmukhtar Habas1, Kalifa Farfar1, Nada Errayes2
1Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
Saudi Journal of Medicine & Medical Sciences
|August 3, 2023
Summary
Wernicke
Area of Science:
- Neurology
- Nutritional Neuroscience
Background:
- Wernicke's encephalopathy (WE) and Korsakoff Syndrome (KS) are distinct neurological disorders often grouped as Wernicke-Korsakoff syndrome.
- WE results from thiamine deficiency, causing diencephalic and mesencephalic dysfunction, presenting with confusion, ophthalmoplegia, nystagmus, and ataxia.
Purpose of the Study:
- To provide an updated review on Wernicke's encephalopathy.
- To cover recent advancements in etiology, pathophysiology, diagnosis, and management of WE.
Main Methods:
- A narrative review of articles published between April 2015 and April 2022.
- Literature search conducted using EMBASE, PubMed, Google Scholar, Google, and Scopus.
Main Results:
- WE, primarily linked to alcoholism, can also arise from other causes like post-bariatric surgery.
- Early diagnosis and intravenous thiamine treatment are crucial for preventing severe complications, reducing morbidity and mortality.
Conclusions:
- Increased awareness among physicians and patients is vital for timely diagnosis and treatment of WE.
- Prompt intervention with thiamine is essential for managing WE and improving patient outcomes.
Keywords:
Alcohol use disorderWernicke’s encephalopathyWernicke’s triadbariatric surgeryophthalmoplegiathiaminevitamin B1More Related Videos
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