Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Area of Science:

• Analytical Chemistry
• Spectroscopy
• Pharmaceutical Science

Background:

• Terahertz time-domain spectroscopy (THz-TDS) is a powerful analytical technique.
• It utilizes terahertz pulses to probe physical and chemical properties of materials.
• THz-TDS presents a non-destructive, efficient, and convenient approach for spectral detection in pharmaceutical analysis.

Purpose of the Study:

• To review the advancements in THz-TDS for pharmaceutical analysis over the last decade.
• To assess the scientific feasibility of applying THz-TDS in practical pharmaceutical detection.
• To discuss current challenges and future prospects of THz-TDS in pharmaceutical applications.

Main Methods:

• Review of research achievements in THz-TDS for chemical drugs, traditional Chinese medicine, and biological drugs.
• Analysis of the working principle of THz-TDS.
• Discussion on the practical application and future development of THz-TDS.

Main Results:

• Significant research progress has been made in applying THz-TDS to analyze various pharmaceutical types.
• The technology demonstrates scientific feasibility for practical pharmaceutical detection.
• Identified challenges and prospects for future development in the field.

Conclusions:

• THz-TDS is a promising technology for pharmaceutical analysis.
• Further development is needed to overcome practical application challenges.
• This review serves as a reference for future THz-TDS applications in pharmaceuticals.