Related Experiment Video
Updated: Jul 20, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.3K
Association between selenium intake and migraine: a nationwide cross-sectional study
Leiyong Zhao1, Jiahui Yin2, Xiaotong Li2
1Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in Neuroscience
|August 3, 2023
Summary
The relationship between selenium intake and migraine is non-linear. Migraine risk decreased with selenium intake up to 93.1 mcg/day, with no significant association thereafter.
Area of Science:
- Nutritional Science
- Neurology
- Epidemiology
Background:
- Dietary interventions for migraine are increasingly researched.
- The specific link between selenium intake and migraine prevalence is not well-established.
- Understanding nutrient associations is crucial for dietary migraine management.
Purpose of the Study:
- To investigate the association between selenium intake and migraine.
- To determine if the relationship is linear or non-linear.
- To identify potential thresholds for selenium's effect on migraine.
Main Methods:
- Multivariate logistic regression analysis was employed.
- Restricted cubic splines were used to assess non-linear relationships.
- Stratified analysis explored population differences, including obesity status.
Main Results:
- A non-linear association between selenium intake and migraine was identified.
- An inflection point was observed at 93.1 mcg/day of selenium intake.
- Migraine odds decreased with selenium intake below the inflection point; no significant association was found above it, except in non-obese individuals.
Conclusions:
- A non-linear relationship exists between selenium intake and migraine in the U.S. population.
- Selenium intake below 93.1 mcg/day may be associated with reduced migraine odds.
- Further research is warranted to elucidate the clinical implications of this non-linear association.
