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Ameliorating Racial Disparities in Vascular Risk Factor Management With Aggressive Medical Management in the SAMMPRIS
Eyad Almallouhi1,2, Ashley M Nelson1, George Cotsonis3
1Department of Neurology (E.A., A.M.N., M.I.C., T.N.T.), Medical University of South Carolina.
Stroke
|August 3, 2023
Summary
Aggressive medical management in the SAMMPRIS trial helped resolve baseline disparities in diastolic blood pressure and physical activity between Black and non-Black patients with intracranial stenosis.
Area of Science:
- Neurology
- Cardiovascular Disease
- Public Health
Background:
- Symptomatic intracranial atherosclerotic stenosis requires optimal management strategies.
- Previous trials like WASID and SAMMPRIS evaluated treatment options.
- This study investigates risk factor control disparities in Black versus non-Black patients within the SAMMPRIS trial.
Purpose of the Study:
- To determine if aggressive medical management ameliorated risk factor control disparities between Black and non-Black patients.
- To analyze baseline and 1-year follow-up data from the SAMMPRIS trial.
Main Methods:
- Retrospective, observational analysis of the SAMMPRIS randomized controlled trial data.
- Comparison of risk factors (hypertension, diabetes, blood pressure, LDL, exercise) at baseline and 1 year between Black and non-Black patient groups.
- Statistical analysis of demographic and clinical data.
Main Results:
- Significant baseline differences observed between Black and non-Black patients in age, hypertension, diabetes, diastolic blood pressure, and exercise score.
- By 1-year follow-up, disparities in diastolic blood pressure and exercise scores between the groups were no longer significant.
- No other modifiable risk factor disparities were evident at 1 year.
Conclusions:
- Aggressive medical management in the SAMMPRIS trial effectively resolved baseline disparities in diastolic blood pressure and physical activity.
- These findings suggest a potential role for aggressive medical management in reducing health disparities in patients with intracranial stenosis.
- Further research may explore the long-term impact of such management on stroke recurrence across different racial groups.
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