[Continuous monitoring of subcutaneous glucose concentration using implanted enzyme electrodes]

The subcutaneous glucose concentration was continuously monitored in the neck of healthy unanaesthetized dogs employing a miniaturized glucose oxidase/H2O2 sensor. Under steady state conditions it amounted to approximately 50% of the circulating level. Induced alterations (oral or intravenous glucose loads) were mirrored with a delay, which was mainly determined by the sensor characteristics. Minor alterations in circulating glucose concentration (e.g. from 4.5 up to 7.5 mmol/l within 60 min) as induced by the oral load do not alter the concentration ratio between interstitial glucose and glycoemia.