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Safety, Feasibility, and Acceptability of a Multisite Individualized Exercise Intervention for People with Multiple
Jennifer L Nicol, Brent J Cunningham1, Carmel Woodrow2
1School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, AUSTRALIA.
Medicine and Science in Sports and Exercise
|August 3, 2023
Summary
An individualized exercise program for multiple myeloma (MM) patients is safe and acceptable. However, adherence to exercise protocols was limited by symptoms, indicating a need for improved strategies for unsupervised exercise in this population.
Area of Science:
- Oncology
- Exercise Science
- Clinical Trials
Background:
- Multiple myeloma (MM) patients often experience debilitating symptoms impacting exercise safety and feasibility.
- Uncertainty exists regarding the optimal exercise approach for MM patients across all disease stages.
Purpose of the Study:
- To determine the safety, feasibility, and acceptability of an individualized, high-intensity exercise program for multiple myeloma patients.
- To assess the impact of exercise on individuals with multiple myeloma at any disease stage.
Main Methods:
- A 12-week, multisite, randomized waitlist-controlled trial involving an individualized, high-intensity aerobic, resistance, and impact-loading exercise program.
- Supervised exercise sessions twice weekly, with one unsupervised session weekly, led by accredited exercise physiologists.
- Safety assessed via adverse events; feasibility by eligibility, recruitment, adherence, and attrition; acceptability via interviews and enjoyment ratings.
Main Results:
- The study enrolled 60 participants with 20% attrition, meeting feasibility criteria.
- No adverse or serious adverse events were reported, confirming program safety.
- High acceptability (82%) was reported, though adherence to unsupervised sessions (45% completion) and specific protocols (34%-63%) was limited by comorbidities and symptoms.
Conclusions:
- An individualized, high-intensity exercise program is safe and acceptable for multiple myeloma patients.
- Feasibility is demonstrated by safety and acceptability, but adherence requires further investigation.
- Strategies to enhance unsupervised exercise completion are crucial for improving outcomes in this population.
