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Related Experiment Video

Updated: Jul 20, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Turning the tide on obesity?

Cynthia M Bulik¹, J Andrew Hardaway²

¹Cynthia M. Bulik is a professor in the Department of Psychiatry and the Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, and in the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Science (New York, N.Y.)

|August 3, 2023

Summary

The obesity epidemic involves genetics, diet, and lifestyle factors. New weight-loss drugs may offer a path to overcoming these challenges, potentially closing the "fat decades" in public health.

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Area of Science:

Public Health
Obesity Research
Metabolic Science

Background:

The global obesity epidemic is multifactorial, with genetics, ultraprocessed foods, portion distortion, sweetened beverages, screen time, food addiction, intestinal microbiota, diet culture, weight stigma, and food insecurity all implicated.
Over one billion individuals worldwide currently live with obesity, and a larger proportion are overweight, highlighting a critical public health crisis.

Discussion:

The complex interplay of genetic predispositions and environmental factors, including modern dietary patterns and lifestyle habits, contributes significantly to the rising prevalence of obesity.
Societal issues such as diet culture and weight stigma, alongside systemic problems like food insecurity, exacerbate the obesity epidemic, affecting diverse populations globally.

Key Insights:

Emerging pharmacological interventions, specifically highly effective weight-loss drugs, represent a significant advancement in managing obesity.
These novel treatments offer a potential paradigm shift, moving beyond traditional lifestyle interventions to address the biological underpinnings of obesity.

Outlook:

The advent of potent weight-loss medications may signal a turning point, potentially mitigating the long-term public health burden associated with obesity.
Future public health strategies may integrate pharmacological approaches with existing efforts to combat the multifaceted drivers of the obesity epidemic.