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Standardizing clinical laboratory data for the development of transferable computer-based diagnostic programs.

P W Strike, A Michaeloudis, A J Green

    Clinical Chemistry
    |January 1, 1986
    PubMed
    Summary
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    Eliminate inter-laboratory bias in pathology test results using standard unit transformations. This ensures consistent data for developing comprehensive reference databases and interpretive programs.

    Area of Science:

    • Pathology
    • Laboratory Medicine
    • Biostatistics

    Background:

    • Systematic differences in pathology test results across laboratories hinder the creation of universal reference databases.
    • Inter-laboratory bias can compromise the accuracy and comparability of diagnostic data.

    Purpose of the Study:

    • To review and describe methods for eliminating inter-laboratory bias in pathology.
    • To introduce a general transformation procedure for standardizing pathology test results.

    Main Methods:

    • Review of existing approaches to inter-laboratory bias elimination.
    • Description of standard unit transformations for data normalization.
    • Presentation of a general transform procedure for pathology data.

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    Main Results:

    • Standard unit transformations effectively eliminate systematic differences between laboratory results.
    • The proposed general transform procedure allows laboratories to utilize larger, shared clinical databases.
    • Consistent data enables the development of more robust reference data and interpretive programs.

    Conclusions:

    • Eliminating inter-laboratory bias through unit transformations is crucial for interpretive pathology.
    • Standardization facilitates the creation of accessible, reliable reference databases.
    • This approach enhances the utility of clinical databases for individual laboratories.