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Updated: Jul 20, 2025

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Osteomyelitis and Septic Arthritis of the Foot and Ankle: Imaging Update
Islam Zaki1, William B Morrison2
1Department of Radiology, Benha University Hospital, El-Shaheed Farid Nada, Qism Banha, Al Qalyubia Governorate, Banha, Egypt.
Abstract:
Radiography is considered the first-line screening exam for clinically suspected osteomyelitis. However, additional evaluation is generally needed. MRI is the definitive diagnostic exam with high sensitivity and specificity combined with excellent anatomic definition. Gadolinium contrast can be useful to detect areas of devitalization before surgery. Bone marrow edema on fluid-sensitive images and low signal intensity on T1-weighted images in the presence of secondary MRI findings, including ulcer, sinus tract, and cellulitis with or without abscess are typical findings of osteomyelitis. If MRI is contraindicated, three phase bone scan can be used. Early diagnosis and treatment is essential.
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