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Updated: Jul 20, 2025
Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos
Published on: August 25, 2019
Assessment of Risperidone Toxicity in Zebrafish (Danio rerio) Embryos
Hirla Costa Silva Fukushima1, Ricardo Lacava Bailone2, Ricardo Carneiro Borra3
1Center of Biological and Health Sciences, Federal University of São Carlos, São Carlos, Brazil; Corresponding Author. hirlafukushima@gmail. com.
Abstract:
Risperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goal of the current study was to examine the effects of risperidone in zebrafish embryos ( Danio rerio ) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.
