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Transcriptomic risk scores for attention deficit/hyperactivity disorder
Judit Cabana-Domínguez1,2,3,4, Natalia Llonga5,6, Lorena Arribas5,6
1Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. judit.cabana@vhir.org.
This study reveals that transcriptomic risk scores (TRSs) derived from gene expression in blood are associated with Attention Deficit/Hyperactivity Disorder (ADHD). Combining TRSs with polygenic risk scores (PRS) enhances ADHD prediction, offering new insights into the disorder.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Attention Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder with high heritability.
- Understanding the genetic and molecular underpinnings of ADHD is crucial for improved diagnosis and treatment.
Conclusions:
- Transcriptomic profiles in blood, captured by TRSs, offer complementary predictive value for ADHD.
- Gene expression data holds potential for enhancing ADHD risk prediction and elucidating molecular mechanisms.
- The integration of genetic and transcriptomic information may lead to more comprehensive ADHD assessment.
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