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Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

131
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Transcriptomic risk scores for attention deficit/hyperactivity disorder.

Judit Cabana-Domínguez1,2,3,4, Natalia Llonga5,6, Lorena Arribas5,6

  • 1Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. judit.cabana@vhir.org.

Molecular Psychiatry
|August 3, 2023
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Summary

This study reveals that transcriptomic risk scores (TRSs) derived from gene expression in blood are associated with Attention Deficit/Hyperactivity Disorder (ADHD). Combining TRSs with polygenic risk scores (PRS) enhances ADHD prediction, offering new insights into the disorder.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Attention Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder with high heritability.
  • Understanding the genetic and molecular underpinnings of ADHD is crucial for improved diagnosis and treatment.

Conclusions:

  • Transcriptomic profiles in blood, captured by TRSs, offer complementary predictive value for ADHD.
  • Gene expression data holds potential for enhancing ADHD risk prediction and elucidating molecular mechanisms.
  • The integration of genetic and transcriptomic information may lead to more comprehensive ADHD assessment.