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A sequence analysis system encompassing rules for DNA helical distortion.

B A Shapiro, R Nussinov, L E Lipkin

    Nucleic Acids Research
    |January 10, 1986
    PubMed
    Summary
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    DNA structural distortions from steric clashes between purines and pyrimidines can be quantified. These DNA perturbations may carry information for external interactions, prompting a system for pattern exploration.

    Area of Science:

    • Molecular Biology
    • Structural Biology
    • Bioinformatics

    Background:

    • DNA structure is influenced by steric clashes between bases.
    • These distortions can affect DNA's function and interactions.
    • Previous work quantified distortions using four sum functions.

    Purpose of the Study:

    • To describe a system for exploring DNA structural patterns.
    • To investigate information carried by DNA structural perturbations.
    • To analyze consequences of steric clashes in DNA.

    Main Methods:

    • Utilizing four established sum functions for DNA distortion quantification.
    • Developing a system for interactive exploration of DNA structures.
    • Incorporating various functions to analyze steric clash patterns.

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    Main Results:

    • Demonstrated a system for analyzing DNA structural variations.
    • Identified potential information carriers within DNA structure.
    • Facilitated systematic exploration of steric clash-induced patterns.

    Conclusions:

    • DNA steric clashes result in quantifiable structural perturbations.
    • These perturbations may serve as carriers of biological information.
    • The developed system allows for systematic investigation of these patterns.