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Controllable mitochondrial aggregation and fusion by a programmable DNA binder.

Longyi Zhu1, Yiting Shen1, Shengyuan Deng2

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Scientists developed a synthetic DNA binder to control mitochondria in living cells. This programmable tool induces mitochondrial aggregation and fusion, repairing stressed neuron cells and offering potential for precision therapy.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Background:

  • DNA nanodevices show promise in chemo-biological applications.
  • Precise regulation of intracellular organelles using nanodevices remains a challenge.

Purpose of the Study:

  • To develop a synthetic DNA binder for artificial induction of mitochondrial aggregation and fusion.
  • To explore the potential of this DNA binder in repairing ROS-stressed neuron cells.

Main Methods:

  • Designing a DNA binder with a long DNA chain grafted with mitochondria-targeting modules.
  • Investigating the *in situ* self-assembly of mitochondria induced by the DNA binder in living cells.
  • Incorporating customized molecular switches for stimuli-triggered organelle manipulation.

Main Results:

  • The synthetic DNA binder successfully induced mitochondrial aggregation and fusion in living cells.
  • The DNA binder effectively repaired reactive oxygen species (ROS)-stressed neuron cells.
  • The DNA binder design demonstrated high programmability for stimuli-responsive organelle control.

Conclusions:

  • The developed DNA binder is a powerful tool for subcellular manipulation.
  • This technology holds significant potential for precision therapy and organelle regulation.
  • Programmable DNA nanodevices offer new avenues for biomedical interventions.