Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal tubular dysfunction in transplanted kidneys.

N D Vaziri, R E Nellans, R M Brueggemann

    Southern Medical Journal
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The severity and frequency distribution of endometriosis subtypes at different ages: a model to understand the natural history of endometriosis based on single centre/single surgeon data.

    Facts, views & vision in ObGyn·2021
    Same author

    Corrigendum. Nonvisualized palpable bowel endometriotic satellites.

    Human reproduction (Oxford, England)·2021
    Same author

    Nonvisualized palpable bowel endometriotic satellites.

    Human reproduction (Oxford, England)·2021
    Same author

    Correction: Heterogeneity of endometriosis lesions requires individualisation of diagnosis and treatment and a different approach to research and evidence based medicine.

    Facts, views & vision in ObGyn·2020
    Same author

    Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review.

    Facts, views & vision in ObGyn·2020
    Same author

    Heterogeneity of endometriosis lesions requires individualisation of diagnosis and treatment and a different approach to research and evidence based medicine.

    Facts, views & vision in ObGyn·2019
    Same journal

    SMA's 6th Annual Physicians-in-Training Leadership Conference Abstract Presentations.

    Southern medical journal·2026
    Same journal

    Potential Impact of Lower Federal Loan Availability on Medical Education in Appalachia.

    Southern medical journal·2026
    Same journal

    Experiential Mentorship Skills Training: The Effect on Real-Life Mentoring.

    Southern medical journal·2026
    Same journal

    Social Pressure: How Early Social Context Shapes Career Interest in Medicine.

    Southern medical journal·2026
    Same journal

    Comparing Speed and Accuracy of Artificial Intelligence Large Language Models on the Orthopedic In-Training Examination.

    Southern medical journal·2026
    Same journal

    Don't Wait to Talk about Weight: A 2-Hour Interactive Curriculum Improves Medical Student Skills with Weight Management.

    Southern medical journal·2026
    See all related articles

    Renal transplant recipients often show tubular dysfunction, particularly impaired tubular reabsorption of phosphorus. This phosphorus handling defect is the most significant finding in kidney transplant patients, even without clear causes.

    Area of Science:

    • Nephrology
    • Transplantation Medicine
    • Renal Physiology

    Background:

    • Renal transplant recipients are susceptible to various complications.
    • Tubular dysfunction can impact long-term graft survival and patient health.
    • Understanding these dysfunctions is crucial for patient management.

    Purpose of the Study:

    • To investigate the prevalence and nature of tubular dysfunction in renal transplant recipients.
    • To identify potential contributing factors to observed tubular abnormalities.
    • To highlight the significance of phosphorus reabsorption defects.

    Main Methods:

    • Studied 15 renal transplant recipients.
    • Assessed for hypophosphatemia, systemic acidosis, and urinary acidification defects.

    Related Experiment Videos

  • Measured aminoaciduria, bicarbonaturia, and parathyroid hormone levels.
  • Evaluated tubular reabsorption of phosphorus and compared with 14 control subjects.

    • Main Results:

    • Eight of 15 patients were hypophosphatemic.
    • Two patients exhibited systemic acidosis with urinary acidification defects.
    • Defective tubular reabsorption of phosphorus was the most prominent abnormality, observed in all hypophosphatemic patients.
    • No clear correlation was found with immunosuppressant therapy, PTH levels, creatinine clearance, or acid-base balance.

    Conclusions:

    • Defective tubular reabsorption of phosphorus is a significant finding in renal transplant recipients.
    • The pathogenesis of this tubular dysfunction remains unclear.
    • Further research is needed to elucidate the underlying mechanisms and clinical implications.