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Description of two new HLA alleles: HLA-DRB1*09:01:12 and HLA-DRB1*09:49

Fang Wang1,2, Ying Li1,2, Nanying Chen1,2

  • 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.

HLA
|August 4, 2023
PubMed

Insights

Two novel Human Leukocyte Antigen (HLA) DRB1 alleles, HLA-DRB1*09:01:12 and HLA-DRB1*09:49, were identified. Both differ from the common HLA-DRB1*09:01:02:01 allele by a single nucleotide substitution.

Area of Science:

  • Immunogenetics
  • Molecular biology

Background:

  • Human Leukocyte Antigen (HLA) genes are crucial for immune response.
  • Polymorphisms in HLA genes, particularly HLA-DRB1, influence immune system diversity and disease susceptibility.
  • Accurate HLA typing is essential for transplantation and understanding autoimmune diseases.

Purpose of the Study:

  • To report the discovery and characterization of two new HLA-DRB1 alleles.
  • To detail the specific genetic variations distinguishing these novel alleles from known ones.

Main Methods:

  • High-resolution HLA typing methodologies were employed.
  • Nucleotide sequencing was used to identify specific variations within the HLA-DRB1 gene.

Main Results:

  • Two novel HLA-DRB1 alleles, designated HLA-DRB1*09:01:12 and HLA-DRB1*09:49, were identified.
  • Both new alleles exhibit a single nucleotide substitution when compared to the reference allele HLA-DRB1*09:01:02:01.

Conclusions:

  • The discovery of novel HLA-DRB1 alleles expands the known HLA genetic diversity.
  • These findings contribute to a more comprehensive understanding of HLA polymorphism and its implications in immunogenetics.

Keywords:
HLA-DRB1*09:01:12HLA-DRB1*09:49next generation sequencingnovel allele

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