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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
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Updated: Jul 20, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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[Light chain amyloidosis].

Ute Hegenbart1, Fabian Aus dem Siepen2, Stefan Schönland3

  • 1Amyloidose-Zentrum, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland. ute.hegenbart@med.uni-heidelberg.de.

Innere Medizin (Heidelberg, Germany)
|August 4, 2023
PubMed
Summary

Light chain amyloidosis (AL) is a rare plasma cell disorder affecting organs, especially the heart. Early diagnosis and chemotherapy to reduce light chains are crucial for effective treatment and survival.

Area of Science:

  • Hematology
  • Oncology
  • Nephrology
Keywords:
AL amyloidosis, systemicAmyloidosis/prognosisAmyloidosis/stagingAmyloidosis/treatmentMonoclonal gammopathy

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