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Kidney fibrosis: Emerging diagnostic and therapeutic strategies

Barbara Mara Klinkhammer1, Peter Boor2

  • 1Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.

Molecular Aspects of Medicine
|August 4, 2023
PubMed

Insights

Chronic kidney disease (CKD) involves kidney fibrosis, a key progression predictor. This review explores new diagnostic tools and therapies to combat fibrosis and improve patient outcomes.

Area of Science:

  • Nephrology
  • Pathology
  • Translational Medicine

Background:

  • Chronic kidney disease (CKD) affects millions globally, characterized by progressive kidney fibrosis.
  • Kidney fibrosis impacts glomeruli, tubulointerstitium, and vasculature, serving as a primary indicator of disease progression.
  • Current management lacks specific anti-fibrotic treatments, and diagnosis relies on invasive renal biopsies.

Purpose of the Study:

  • To review emerging diagnostic strategies for kidney fibrosis.
  • To explore potential therapeutic interventions for renal fibrosis.
  • To discuss the role of translational research in developing anti-fibrotic therapies and companion diagnostics for CKD.

Main Methods:

  • Literature review of current research on kidney fibrosis diagnostics and therapeutics.
  • Analysis of translational research findings relevant to clinical applications.
  • Discussion of clinical trial endpoint development for anti-fibrotic drug evaluation.

Main Results:

  • Emerging diagnostic approaches offer non-invasive alternatives for fibrosis detection and quantification.
  • Several therapeutic strategies are under investigation for targeting kidney fibrosis.
  • Translational research is crucial for validating new endpoints and facilitating drug development.

Conclusions:

  • Novel diagnostic and therapeutic strategies are needed to address kidney fibrosis in CKD.
  • Advancements in translational research can accelerate the development of effective anti-fibrotic treatments.
  • Improved patient stratification and companion diagnostics will optimize the management of kidney fibrosis.
Keywords:
ElastographyLiquid biomarkerNon-invasive imagingPrecision medicineSGLT-2

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