Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

622
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
622
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

364
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
364
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

16
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
16
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

23
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
23
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

463
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
463
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

22
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
22

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Venous return versus cardiac function: who drives the circulation?

Intensive care medicine·2026
Same author

Venous waterfalls mainly buffer backward pressure transmission.

Intensive care medicine experimental·2026
Same author

Three decades of hemodynamic monitoring (1995-2025): from invasive pressure based hemodynamic profiling to functional physiology.

Current opinion in critical care·2026
Same author

A comprehensive cross-sectional study of bedside monitor alarm characteristics and alarm load across hospital units.

Scientific reports·2026
Same author

The Effective Management of Shock: Moving From Physiology to Guidelines to Personalized Medicine.

Critical care medicine·2026
Same author

Defining the Determinants of Tissue Perfusion at the Bedside in Septic Shock Patients.

Anesthesiology·2026
Same journal

Monographic Issue on New Concepts in Acute Exacerbations of COPD.

Seminars in respiratory and critical care medicine·2026
Same journal

Bidirectional Clinical Interactions among Exacerbations and Comorbidities in COPD: A Narrative Review.

Seminars in respiratory and critical care medicine·2026
Same journal

Radiological Approach to Severe Respiratory Infections and Pulmonary Complications in Immunocompromised Patients.

Seminars in respiratory and critical care medicine·2026
Same journal

Two Sides of the Same Smoke: Decoding Respiratory Bronchiolitis-Associated Interstitial Lung Disease and Alveolar Macrophage Pneumonia.

Seminars in respiratory and critical care medicine·2026
Same journal

Role of Vaccination in the Prevention of ECOPD.

Seminars in respiratory and critical care medicine·2026
Same journal

Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Pharmacological Treatment of AECOPD New Perspectives.

Seminars in respiratory and critical care medicine·2026
See all related articles

Related Experiment Video

Updated: Jul 20, 2025

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.2K

Heart-Lung Interactions.

Natsumi Hamahata1, Michael R Pinsky1

  • 1Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Seminars in Respiratory and Critical Care Medicine
|August 4, 2023
PubMed
Summary
This summary is machine-generated.

The interaction between the lungs and heart significantly impacts cardiac function. Understanding heart-lung interactions is crucial for managing patients with cardiovascular conditions, especially during mechanical ventilation.

More Related Videos

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
06:16

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration

Published on: May 29, 2015

8.4K
Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

806

Related Experiment Videos

Last Updated: Jul 20, 2025

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.2K
Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
06:16

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration

Published on: May 29, 2015

8.4K
Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

806

Area of Science:

  • Cardiology
  • Pulmonology
  • Critical Care Medicine

Background:

  • The pulmonary and cardiovascular systems are intricately linked, with lung mechanics influencing cardiac function.
  • Cardiac output is determined by heart rate, preload, contractility, and afterload, all of which can be affected by respiratory changes.
  • Changes in lung volume, intrathoracic pressure (ITP), and oxygen levels can profoundly impact hemodynamic determinants.

Conclusions:

  • Heart-lung interaction is a dynamic process influenced by respiratory status and patient's volume status.
  • Understanding these interactions is vital for optimizing mechanical ventilation strategies and managing cardiovascular stability.
  • Techniques like pulse pressure variation and stroke volume variation leverage these interactions to assess fluid responsiveness.