Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

196
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
196
Drug Dependence01:17

Drug Dependence

1.1K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.1K
Blind Procedures02:07

Blind Procedures

10.7K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

End-to-end extraction of temporal information from psychiatric discharge summaries.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science·2026
Same author

Exploration of NMDA and GABA receptor-mediated plasticity induced by 10-Hz repetitive transcranial magnetic stimulation.

Translational psychiatry·2026
Same author

Smartphone-based cognitive assessment in older adults with depression: Feasibility and task performance using ecological momentary assessment.

Journal of affective disorders·2026
Same author

Modeling the effects of routine screening for accidental lab-acquired infections on the risk of potential pandemic pathogen escape from high-biosafety research facilities.

Frontiers in bioengineering and biotechnology·2026
Same author

Paranoia, experiential avoidance, and narcissism as predictors of outcome in residential treatment of borderline personality disorder.

Frontiers in psychiatry·2026
Same author

A Self-Driving and Self-Reporting Petal-Like Au-Cu<sub>2</sub>O Metalloenzyme for Probing H<sub>2</sub>S-Mediated Cuproptosis.

ACS nano·2026
Same journal

Mental and somatic multimorbidity among individuals with alcohol use disorder: A sex-stratified registry study.

Drug and alcohol dependence·2026
Same journal

Monitoring novel psychoactive substance trends on social media: Analysis of discussions and dashboard implementation.

Drug and alcohol dependence·2026
Same journal

A meta-analysis on the relationship between cultural identity and substance use among indigenous youth.

Drug and alcohol dependence·2026
Same journal

Examining heterogeneity in pathways between alcohol-related factors and drinking during topiramate pharmacotherapy: A person-specific analysis.

Drug and alcohol dependence·2026
Same journal

The impact of severe mental illness on treatment retention and all-cause mortality among people in opioid agonist treatment.

Drug and alcohol dependence·2026
Same journal

Does treatment status matter? An examination of daily approach and avoidance inclinations predicting drinking in individuals diagnosed with alcohol use disorder.

Drug and alcohol dependence·2026
See all related articles

Related Experiment Video

Updated: Jul 20, 2025

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.6K

Methods for handling missing binary data in substance use disorder trials.

Boyu Ren1, Stuart R Lipsitz2, Roger D Weiss3

  • 1Laboratory for Psychiatric Biostatistics, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Drug and Alcohol Dependence
|August 6, 2023
PubMed
Summary
This summary is machine-generated.

Missing data in substance use disorder (SUD) trials are common and complex. This study reviews methods for handling non-monotone missing data, offering recommendations for more principled analysis and reporting in SUD research.

Keywords:
DropoutMissing at randomMissing dataMissing not at randomNon-monotone missingnessSensitivity analysis

More Related Videos

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

9.8K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

947

Related Experiment Videos

Last Updated: Jul 20, 2025

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.6K
A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

9.8K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

947

Area of Science:

  • Clinical Trials
  • Biostatistics
  • Substance Use Disorder Research

Background:

  • Longitudinal substance use disorder (SUD) clinical trials frequently encounter high rates of missing data.
  • Non-monotone missing data patterns, where participants intermittently skip assessments, are common and challenging.
  • Missing data are often missing not at random (MNAR), particularly when the outcome is substance use.

Purpose of the Study:

  • To review conventional and novel methods for handling non-monotone missing data in SUD trials.
  • To compare and contrast these methods using data from a real-world clinical trial.
  • To provide recommendations for the SUD research community on principled missing data handling.

Main Methods:

  • Review of statistical approaches for missing data in longitudinal studies.
  • Application and comparison of methods to binary outcomes in SUD trials.
  • Analysis of data from the Collaborative Cocaine Treatment Study.

Main Results:

  • Conventional methods for monotone missing data are insufficient for non-monotone patterns.
  • Novel methods offer more robust approaches for handling intermittent missingness.
  • The study highlights differences in results based on the chosen missing data method.

Conclusions:

  • Principled methods for handling non-monotone missing data are crucial for accurate SUD trial results.
  • Recommendations are provided for improving the analysis and reporting of missing data in SUD research.
  • Adoption of advanced methods can enhance the reliability of findings in substance use disorder clinical trials.