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Published on: May 23, 2021
Evolving microbial patterns of acute mastoiditis in pediatric patients undergoing mastoidectomy
Troy Wesson1, Dhruv Sharma2, Cole Rodman2
1Indiana University School of Medicine, Indianapolis, IN, USA.
Insights
Streptococcus pyogenes and Streptococcus pneumoniae were the most common bacteria in pediatric mastoiditis cases requiring surgery. Negative intra-operative cultures correlated with longer hospital stays and increased need for central venous access.
Area of Science:
- Otolaryngology
- Pediatric Infectious Diseases
- Microbiology
Background:
- Acute coalescent mastoiditis is a serious middle ear infection requiring surgical intervention.
- Understanding the microbial landscape and clinical outcomes post-mastoidectomy is crucial for optimizing patient care.
Purpose of the Study:
- To analyze microbial pathogens identified during mastoidectomy for acute coalescent mastoiditis in pediatric patients.
- To correlate microbial findings with clinical outcomes, including length of stay and complications.
- To identify factors predicting prolonged treatment or adverse outcomes.
Main Methods:
- A retrospective cohort study was conducted at a tertiary pediatric hospital.
- Data from 46 pediatric patients undergoing mastoidectomy for acute coalescent mastoiditis between 2010 and 2019 were analyzed.
- Statistical analyses included T-tests, logistic regression, and multivariate analysis to identify significant predictors.
Main Results:
- Streptococcus pyogenes and Streptococcus pneumoniae were the most frequent bacteria identified.
- A significant proportion of cultures (35.4%) showed no bacterial growth.
- Patients with negative cultures experienced longer hospital stays and higher rates of peripherally inserted central catheter (PICC) placement.
- Female gender was identified as a significant predictor of positive culture status on multivariate analysis.
Conclusions:
- The predominant pathogens in pediatric mastoiditis requiring mastoidectomy are S. pyogenes and S. pneumoniae.
- Negative intra-operative wound cultures are associated with poorer clinical outcomes, including extended hospital stays and increased need for PICC lines.
- Further research may explore the implications of negative cultures in guiding treatment strategies.
Objective:
To investigate the microbial patterns and clinical outcomes of pediatric patients undergoing mastoidectomy for acute coalescent mastoiditis and to identify factors associated with poor outcomes and/or prolonged treatment.
Study Design:
Monocentric retrospective cohort study.
Setting:
Tertiary referral pediatric hospital in Indiana.
Methods:
By cross-referencing database data from the Pediatric Health Information System (PHIS) querying for all inpatient stays (patients younger than eighteen) with a diagnostic code of mastoiditis between January 1st, 2010 and August 31, 2019, and the electronic health record (Cerner) for Riley Hospital for Children, 46 patients with mastoidectomy were included. A two-tailed T-test was used to evaluate continuous parametric data. Statistical significance was determined as P < 0.05. For continuous variables, data was analyzed using continuous logistic regression. A criteria of p > 0.1 was used for inclusion in the multivariate regression.
Results:
Inclusion criteria was met by 46 patients. From 2010 to 2019, S. pyogenes and S. pneumoniae were the most common bacteria, each isolated in 11 of 42 bacterial isolates (26.2%). There was no growth in 35.4% (17/48) of intra-operative wound cultures. On univariate analysis, patients with negative cultures had longer length of hospital stay (LOS) (7.7 days [6.5] vs. 4.3 [2.8]; p = 0.018) as well as higher rates of PICC (peripherally inserted central catheter) placement (53.3% vs. 19.4%; p = 0.021). There was a statistically significant difference in terms of gender (p = 0.021), with 15 males and 16 females in the positive culture cohort and 13 males and 2 females in the negative culture cohort. On multivariate analysis, which included gender, PICC placement, both intracranial and extracranial complications, duration of antibiotics, and LOS, female gender was the only significant predictor of positive culture status (p = 0.039).
Conclusion:
S. pyogenes and S. pneumoniae were the predominant etiologic agents in acute coalescent mastoiditis between 2010 and 2019, and negative wound cultures were associated with worse clinical outcomes.
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