[Lipid metabolic disorders in rats with a transplanted Pliss lymphosarcoma]

Changes in biosynthesis of cholesterol and free fatty acids from 2-14C-acetate in the host liver and tumour tissue as well as concentrations of various classes of lipids in blood were determined in rats bearing the transplanted Pliss lymphosarcoma. The transplantation of the tumour stimulates cholesterol biosynthesis de novo in the liver, but produces no changes in the fatty acid synthesis. Tumour growth is accompanied by a progressive increase in the content of triglycerides and beta-lipoproteins with a parallel drop in the alpha-cholesterol level in the animal blood. The concentration of total cholesterol is of phasic character depending on the stage of tumour growth. The possible mechanisms determining such alterations in lipids metabolism are discussed.