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Mechanical Protein Functions01:58

Mechanical Protein Functions

5.0K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
14.8K
Endergonic and Exergonic Reactions in the Cell01:27

Endergonic and Exergonic Reactions in the Cell

15.2K
If energy releases during a chemical reaction, then the resulting value will be a negative number. In other words, reactions that release energy have a ∆G < 0. A negative ∆G also means that the reaction's products have less free energy than the reactants because they gave off some free energy during the reaction. Scientists call reactions with a negative ∆G, and which consequently release free energy, exergonic reactions. Exergonic means energy is exiting the...
15.2K
Coupled Reactions01:17

Coupled Reactions

7.8K
Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions. 
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
7.8K
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

5.6K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
5.6K
Rab Cascades01:25

Rab Cascades

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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Related Experiment Video

Updated: Jul 20, 2025

Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment
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Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment

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Artificial Molecular Ratchets: Tools Enabling Endergonic Processes.

Thitiporn Sangchai1, Shaymaa Al Shehimy1, Emanuele Penocchio2

  • 1University of Strasbourg, CNRS, Institut de Science et d'Ingénierie Supramoléculaires (ISIS) UMR 7006, 8 allée Gaspard Monge, 67000, Strasbourg, France.

Angewandte Chemie (International Ed. in English)
|August 7, 2023
PubMed
Summary
This summary is machine-generated.

Artificial molecular ratchets harness environmental energy for non-equilibrium chemical systems. This review unifies understanding of these mechanisms across diverse scientific fields.

Keywords:
CatalysisMolecular MachinesNon-Equilibrium SystemsPhotoswitchesSystems Chemistry

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Area of Science:

  • Chemistry
  • Chemical Engineering
  • Materials Science

Background:

  • Non-equilibrium chemical systems are crucial for supramolecular chemistry, molecular machines, systems chemistry, prebiotic chemistry, and energy transduction.
  • Experimental chemists are developing artificial systems capable of harvesting energy away from equilibrium.

Purpose of the Study:

  • To provide an overview of artificial molecular ratchets.
  • To explain the chemical mechanisms that enable energy absorption from the environment.
  • To offer a unifying perspective on molecular ratchets by focusing on mechanism type.

Main Methods:

  • This tutorial review synthesizes existing research on artificial molecular ratchets.
  • The focus is on classifying and understanding the fundamental mechanisms of these systems.
  • The review categorizes ratchets based on their underlying chemical principles.

Main Results:

  • Artificial molecular ratchets represent a key mechanism for energy absorption in non-equilibrium systems.
  • Understanding ratchet mechanisms provides a unified view of diverse phenomena in artificial chemical systems.
  • This approach facilitates the design and development of novel energy-harvesting molecular systems.

Conclusions:

  • Artificial molecular ratchets are essential for creating functional non-equilibrium chemical systems.
  • A mechanism-centric approach unifies the study of molecular ratchets.
  • This review aims to foster further progress in the field of artificial molecular machines and systems chemistry.