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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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Biofunctionalization of Magnetic Nanomaterials
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Function from Confinement: Ligand-Coated Nanoparticles as Functional Materials.

Euan R Kay1, Volodymyr Sashuk2, Bartosz A Grzybowski3,4,5

  • 1EaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United Kingdom.

ACS Nano
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

Self-assembled monolayers on nanoparticles offer unique functionalities. This review explores their role in catalysis, sensing, and assembly, highlighting design principles for advanced nanomaterials.

Keywords:
adaptative materialsfunctional nanomaterialsmolecular recognitionnanocatalysisnanoconfinementnanoparticle assemblynanozymesself-assembled monolayerssensingstimuli-responsive

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Nanoparticles stabilized by self-assembled monolayers (SAMs) possess surface-bound molecular species.
  • These organic entities exhibit emergent properties when confined to nanosurfaces, imparting unique functionalities.

Purpose of the Study:

  • To review how structural organization and collective interactions in SAMs on nanoparticles lead to specific functions.
  • To explore applications in catalysis, sensing, switching, and programmable assembly.
  • To identify design principles for hybrid organic-inorganic nanosystems.

Main Methods:

  • Review of literature focusing on quasi-spherical nanoparticles (< 8 nm).
  • Analysis of SAMs' structural organization and collective interactions.
  • Adoption of a systems-chemistry perspective.

Main Results:

  • SAMs on nanoparticles enable functions like nanoconfined catalysis, molecular recognition, and programmable assembly.
  • Design principles are elucidated for creating functional nanoparticles.
  • The organic layer is presented as an active driver of system functionality.

Conclusions:

  • Harnessing the dynamic nature of SAMs allows for sophisticated, programmable nanomaterials.
  • Opportunities exist in active materials, nanocatalysis, sensing, and delivery.
  • A shift in perspective is needed to view SAMs as active functional components.