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Updated: Jul 19, 2025

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Bioactive compounds for human and planetary health.

Martin Kussmann1,2, David Henrique Abe Cunha3,4, Silvia Berciano5

  • 1Kompetenzzentrum für Ernährung (KErn), Freising, Germany.

Frontiers in Nutrition
|August 7, 2023
PubMed
Summary

Edible plant bioactives are key for human and planetary health, offering natural solutions for wellness and disease prevention. Harnessing these compounds requires food system innovation for sustainable, healthy diets.

Keywords:
artificial intelligencebioactivemicronutrientnutritionpeptidephytonutrientprebioticprobiotic

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Area of Science:

  • Nutritional Science
  • Environmental Science
  • Food Science

Background:

  • Bioactive compounds in edible plants and foods are crucial for human and planetary health but are often underappreciated.
  • These natural compounds, as part of diets or supplements, can significantly impact human health and wellness.
  • Advancements in omics, computational biology, and Precision Nutrition are merging nutrition and medicine for preventative and therapeutic healthcare.

Purpose of the Study:

  • To highlight the critical role of bioactive compounds in human and planetary health.
  • To emphasize the need for innovation in food systems for sustainable and healthy nutrition.
  • To explore bioactive-based solutions for addressing planetary health challenges and creating value.

Main Methods:

  • Utilizing omics sciences and computational biology for understanding bioactive-host-microbiome interactions.
  • Applying a systems-oriented approach at both biological and ecosystem levels.
  • Leveraging big data and artificial intelligence to accelerate discovery and validation of bioactives.

Main Results:

  • Elucidating the interplay between bioactives, the human host, and the microbiome.
  • Developing diverse, nutrient-rich, resilient, and high-yield agricultural crops.
  • Promoting informed consumer choices for personal and planetary health benefits.

Conclusions:

  • Investing in bioactive-based solutions offers an opportunity to protect biodiversity and ecosystem health while improving human wellbeing.
  • Innovation in food systems, including alternative proteins and upcycling, is essential for sustainability.
  • Interdisciplinary collaboration is vital for developing practical, food-based solutions to global challenges.