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Human retinal secretome: A cross-link between mesenchymal and retinal cells
Luigi Donato1,2, Concetta Scimone1,2, Simona Alibrandi1,2,3
1Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy.
World Journal of Stem Cells
|August 7, 2023
Summary
Mesenchymal stem cell (MSC) secretomes can protect retinal cells from damage and degeneration. Retinal cell secretomes can also influence MSCs, highlighting a crucial cross-talk for regenerative medicine therapies.
Area of Science:
- Regenerative Medicine
- Ophthalmology
- Cell Biology
Background:
- Mesenchymal stem cells (MSCs) are vital for regenerative medicine, primarily through their secretome (soluble paracrine factors and extracellular vesicles).
- The secretome plays key roles in immunomodulation and tissue repair.
- Retinal cells, like retinal pigment epithelium and Müller glia, also release trophic factors essential for retinal health and injury response.
Purpose of the Study:
- To review the cross-talk between MSC secretomes and retinal cell secretomes in the context of experimental therapies for retinal diseases.
- To highlight the reciprocal influence of these secretomes on each other.
Main Methods:
- Literature review focusing on the secreted factors from MSCs and retinal cells.
- Analysis of experimental studies investigating the therapeutic potential of secretome-based approaches for retinal diseases.
Main Results:
- MSC secretomes protect retinal cells by mitigating oxidative stress, autophagy, and cell death.
- Retinal cell secretomes can modify MSC gene expression and phenotype, influencing their therapeutic capabilities.
- The interaction between MSC and retinal cell secretomes is crucial for modulating biological pathways involved in retinal survival and regeneration.
Conclusions:
- The bidirectional cross-talk between MSC and retinal cell secretomes offers a promising avenue for developing novel regenerative therapies for retinal diseases.
- Understanding and manipulating this secretome interaction can enhance the efficacy of treatments aimed at preserving retinal integrity and function.
