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Updated: Jul 19, 2025
A Protocol for Transcranial Photobiomodulation Therapy in Mice
Published on: November 18, 2018
Photobiomodulation may enhance cognitive efficiency in older adults: a functional near-infrared spectroscopy study
Tsz-Lok Lee1, Agnes S Chan1,2
1Neuropsychology Laboratory, Department of Psychology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Introduction:
The relative oxygenated hemoglobin (HbO) measured using functional near-infrared spectroscopy (fNIRS) has been considered as an index for cognitive loading, with the more difficult the task, the higher the level. A previous study reported that young adults who received transcranial photobiomodulation (tPBM) showed a reduced HbO of a difficult task, suggesting that tPBM may enhance cognitive efficiency. The present study further investigated the effect of tPBM on cognitive efficiency in older adults.
Methods:
Thirty participants received a single tPBM on the forehead for 350 s. Before and after tPBM, their HbO in the visual span task with various difficulties was measured with fNIRS.
Results:
After tPBM, participants exhibited significantly lower HbO in a harder (span 7) but not an easier level (span 2) of the task, but their behavioral performance remained unchanged. In addition, factors affecting the reduction of HbO were examined, and the results showed that individuals with better memory (as measured by a 30-min delayed recall test) showed more reduction of HbO.
Discussion:
The results suggest that tPBM may enhance cognitive efficiency, with individuals with better memory tend to benefit more.
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