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Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and

Chau Wei Ling1, Kamal Sud2,3,4, Rahul Patel5

  • 1Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia. clin6270@uni.sydney.edu.au.

Journal of Nephrology
|August 7, 2023
PubMed
Abstract

Insights

This review assesses antibiotic stability in peritoneal dialysis solutions for treating peritonitis, crucial for combating multidrug-resistant strains. Stability data is available for some antibiotics, but more research is needed for optimal use.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Peritonitis is a common complication of peritoneal dialysis.
  • Multidrug-resistant bacterial strains pose a significant challenge in treating peritonitis.
  • Less commonly prescribed antibiotics may offer alternative treatment options.

Conclusions:

  • Physicochemical stability is not confirmed for all recommended intraperitoneal antibiotics.
  • Further research is necessary to establish antibiotic stability, particularly in icodextrin-based and pH-neutral solutions.
Keywords:
Culture-directed antibioticsPeritoneal dialysis solutionsPeritonitisStability

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